Angiotensin II Receptors
Robert R Ruffolo, Jr. Wyeth Research, Collegeville, Pennsylvania, USA

Series: Handbooks in Pharmacology and Toxicology Volume: 11

List Price: $179.95
Our Price: $161.95

Cat. #: 8380 ISBN: 0849383803 Publication Date: 7/13/1994

• Details current information on cloning angiotensin II receptors from a variety of species, discussing molecular structure as well as heterogeneity at the molecular level
• Covers angiotensin II receptor biochemistry, such as receptor heterogeneity and the biochemical basis for subclassification; signal transduction processes; and molecular interactions between angiotensin II receptors and macromolecules linking them to their respective signal transduction processes
• Reviews extensively the structure-activity relationships of angiotensin II receptor agonists and antagonists, emphasizes current nonpeptide antagonists emerging in clinical relevance for the treatment of cardiovascular diseases
• Presents an in-depth review of current pharmacological actions mediated by angiotensin II receptors in animals and humans
• Addresses drug and hormone receptors of the renin-angiotensin system and the pharmacology of angiotensin II receptor agonists and antagonists in animals and humans

This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors.

The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors.

This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide angiotensin II receptor agonists and antagonists. It also presents the pharmacological effects mediated by angiotensin II receptors both in the periphery and in the brain.